Standard Operating Procedure for Trace Analysis of Organic Contaminants by Liquid Chromatography Coupled to Mass Spectrometry (LC-MS), a Part of Nanostructurome Methods Pipeline
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This Standard Operating Procedure (SOP) provides guidelines for the trace analysis of organic contaminants in different matrices using Liquid Chromatography coupled to Mass Spectrometry (LC-MS). It covers key steps such as sample collection, preparation, and extraction, followed by chromatographic separation and mass spectrometric anal-ysis. The SOP ensures accurate quantification and identification of contaminants by em-ploying calibrated standards, internal standards, and quality control measures. The procedure emphasizes adherence to safety protocols, instrument maintenance, and troubleshooting for consistent, reliable results, meeting both regulatory and quality as-surance standards for analytical performance. This SOP is a part of Nanostructurome methods pipeline.
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