Standard Operating Procedure for Trace Analysis of Organic Contaminants by Liquid Chromatography Coupled to Mass Spectrometry (LC-MS), a Part of Nanostructurome Methods Pipeline
Synopsis
This Standard Operating Procedure (SOP) provides guidelines for the trace analysis of organic contaminants in different matrices using Liquid Chromatography coupled to Mass Spectrometry (LC-MS). It covers key steps such as sample collection, preparation, and extraction, followed by chromatographic separation and mass spectrometric anal-ysis. The SOP ensures accurate quantification and identification of contaminants by em-ploying calibrated standards, internal standards, and quality control measures. The procedure emphasizes adherence to safety protocols, instrument maintenance, and troubleshooting for consistent, reliable results, meeting both regulatory and quality as-surance standards for analytical performance. This SOP is a part of Nanostructurome methods pipeline.
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